Ethnobotanical, Phytochemical, and Pharmacologies Aspect of Kaempferia rotunda L. as a Local Herbal Plant with Global Potential: A Review

Aloysia Sri Pujiyanti; Ratna Kusuma; Annisa Nurul Ilmi; Febry Rahmadhani Hasibuan

doi:10.36312/biocaster.v5i3.462

Authors

Aloysia Sri Pujiyanti Biology Department, Faculty of Mathematics and Natural Sciences, Mulawarman University, Barong Tongkok Street Number 4, Samarinda, East Kalimantan 75119, Indonesia
Ratna Kusuma Biology Department, Faculty of Mathematics and Natural Sciences, Mulawarman University, Barong Tongkok Street Number 4, Samarinda, East Kalimantan 75119, Indonesia
Annisa Nurul Ilmi Biology Department, Faculty of Mathematics and Natural Sciences, Mulawarman University, Barong Tongkok Street Number 4, Samarinda, East Kalimantan 75119, Indonesia
Febry Rahmadhani Hasibuan Biology Department, Faculty of Mathematics and Natural Sciences, Mulawarman University, Barong Tongkok Street Number 4, Samarinda, East Kalimantan 75119, Indonesia

DOI:

https://doi.org/10.36312/biocaster.v5i3.462

Keywords:

Ethnobotany, Herbal Medicine, Kaempferia rotunda L., Pharmacology, Phytochemistry

Abstract

Kaempferia rotunda L., also known as kunci pepet, is a local herbal plant with global potential traditionally used in various medicinal practices across Southeast Asia. This review summarizes the ethnobotanical, phytochemical, and pharmacological aspects of Kaempferia rotunda L., to explore its applications in modern medicine. Ethnobotanically, its rhizome has been widely utilized for treating digestive disorders, inflammation, and wound healing. Phytochemical studies reveal that Kaempferia rotunda L., contains flavonoids, alkaloids, phenols, and terpenoids, contributing to its biological activities. Several studies have demonstrated significant anti-inflammatory, antibacterial, antioxidant, and anticancer properties. With the increasing demand for natural-based therapies, further exploration of their active compounds and mechanisms of action is highly relevant. This review aims to provide a broader insight into the pharmaceutical potential of Kaempferia rotunda L., and encourage further research for the development of evidence-based herbal medicine.

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References

Aryantini, D., Astuti, P., Yuniarti, N., & Wahyuono, S. (2023). Bioassay-Guided Isolation of the Antioxidant Constituent from Kaempferia rotunda L. Biodiversitas, 24(6), 3641-3647. https://doi.org/10.13057/biodiv/d240665

Atun, S., & Arianingrum, R. (2017). Characterization of Nanoparticles Produced by Chloroform Fraction of Kaempferia rotunda Rhizome Loaded with Alginic Acid and Chitosan and its Biological Activity Test. Asian Journal of Pharmaceutical and Clinical Research, 10(5), 399-403. https://doi.org/10.22159/ajpcr.2017.v10i5.16936

Atun, S., Arianingrum, R., Sulistyowati, E., & Aznam, N. (2013). Isolation and Antimutagenic Activity of Some Flavanone Compounds from Kaempferia rotunda. International Journal of Chemical and Analytical Science, 4(1), 3-8. https://doi.org/10.1016/j.ijcas.2013.03.004

Chhetri, D., Jyothi, Y., Lalhriatpuii, L., Sohaila, S., & Rachana, G. (2024). Antigenotoxicity of Tuberous Rhizomes of Kaempferia rotunda Linn. in Cyclophosphamide Induced Genotoxicity: In Vitro and In Vivo Study. Indian Journal of Science and Technology, 16(47), 4577-4584. https://doi.org/10.17485/IJST/v16i47.2971

Diastuti, H., Chasani, M., & Suwandri, S. (2020). Antibacterial Activity of Benzyl Benzoate and Crotepoxide from Kaempferia rotunda L. Rhizome. Indonesian Journal of Chemistry, 20(1), 9-15. https://doi.org/10.22146/ijc.37526

Dwira, S., Ariska, T. P., Fadilah, F., Azizah, N. N., & Erlina, L. (2020). Comparison of Cytotoxicity Between Ethyl Acetate and Ethanol Extract of White Turmeric (Kaempferia rotunda) Rhizome Extract Against Hela Cervical Cancer Cell Activity. Pharmacognosy Journal, 12(6), 1297-1302. https://doi.org/10.5530/PJ.2020.12.178

Elshamy, A. I., Mohamed, T. A., Essa, A. F., Abd-Elgawad, A. M., Alqahtani, A. S., Shahat, A. A., Yoneyama, T., Farrag, A. R. H., Noji, M., El-Seedi, H. R., Umeyama, A., Paré, P. W., & Hegazy, M. E. F. (2019). Recent Advances in Kaempferia Phytochemistry and Biological Activity: A Comprehensive Review. Nutrients, 11(10), 1-33. https://doi.org/10.3390/nu11102396

Fauziah, D. T., Herowati, R., & Widodo, G. P. (2020). Uji Aktivitas Antimikroba Ekstrak Kunci Pepet (Kaempferia rotunda L.). Jurnal Kesehatan Dr. Soebandi, 8(2), 154-157. https://doi.org/10.36858/jkds.v8i2.240

Hashiguchi, A., Thawtar, M. S., Duangsodsri, T., Kusano, M., & Watanabe, K. N. (2022). Biofunctional Properties and Plant Physiology of Kaempferia spp.: Status and Trends. Journal of Functional Foods, 92(1), 1-13. https://doi.org/10.1016/j.jff.2022.105029

Imam, A. S., Rout, K. S., Sutar, N., Sharma, S. U., & Sutar, R. (2013). Wound Healing Activity of Kaempferia rotunda Linn Leaf Extract. International Journal of Current Microbiology and Applied Sciences, 2(12), 74-78.

Kabir, S. R., Hossen, A., Zubair, A., Alom, J., Islam, F., Hossain, A., & Kimura, Y. (2011). A New Lectin from the Tuberous Rhizome of Kaempferia rotunda: Isolation, Characterization, Antibacterial and Antiproliferative Activities. Protein & Peptide Letters, 18(11), 1140-1149. https://doi.org/10.2174/092986611797200896

Krishna, A. G., Ansary, P. Y., & Oommen, S. M. (2020). Kaempferia rotunda Linn.-Phytochemical Profile. International Research Journal of Pharmacy and Medical Sciences (IRJPMS), 3(6), 21-24. https://doi.org/10.13140/RG.2.2.13991.37283

Krishnakumar, P., Varghese, M., Joe, M. G., Rajagopal, A., & Varghese, L. (2021). Identification and Bioactivities of Endophytic Fungi from Lagenandra toxicaria Dalz. and Kaempferia rotunda L. Journal of Applied Biology and Biotechnology, 9(4), 117-125. https://doi.org/10.7324/JABB.2021.9416

Kumar, A., Kumar, S., & Navneet, N. (2015). Antimicrobial Activity and Phytochemical Analysis of Kaempferia rotunda L. Rhizomes. Der Pharmacia Lettre, 7(9), 389-395.

Lallo, S., Lee, S., Dibwe, D. F., Tezuka, Y., & Morita, H. (2014). A New Polyoxygenated Cyclohexane and Other Constituents from Kaempferia rotunda and Their Cytotoxic Activity. Natural Product Research, 28(20), 1754-1759. https://doi.org/10.1080/14786419.2014.945175

Mustafaanand, P. H. (2014). In-Vitro Plant Regeneration in Kaempferia rotunda Linn. through Somatic Embryogenesis - A Rare Medicinal Plant. International Journal of Current Microbiology and Applied Sciences, 3(9), 409-414.

Pham, N. K., Nguyen, H. T., & Nguyen, Q. B. (2020). A Review on the Ethnomedicinal Uses, Phytochemistry and Pharmacology of Plant Species Belonging to Kaempferia L. Genus (Zingiberaceae). Pharmaceutical Sciences Asia, 48(1), 1-24. https://doi.org/10.29090/PSA.2021.01.19.070

Ragsasilp, A., Saensouk, P., Pholhiamhan, R., & Saensouk, S. (2018). Ethnobotany of Phu Thai Ethnic Group in Nakhon Phanom Province, Thailand. Walailak Journal of Science and Technology, 15(10), 679-699. https://doi.org/10.48048/wjst.2018.3737

Raslina, H., Dharmawibawa, I. D., & Safnowandi, S. (2018). Diversity of Medicinal Plants in National Park of Rinjani Mountain in Order to Arrange Practical Handout of Phanerogamae Systematics. Bioscientist : Jurnal Ilmiah Biologi, 4(1), 1-6. https://doi.org/10.33394/bioscientist.v4i1.210

Saputera, S., Ludang, Y., Jaya, H. P., & Atikah, T. A. (2023). Analysis of Bioactive Content of White Turmeric Rhizome (Kaempferia rotunda) Growing in Central Kalimantan. International Journal of Biology and Biomedical Engineering, 17(1), 8-15. https://doi.org/10.46300/91011.2023.17.2

Seno, D. S. H., Larasati, C., Kamila, F., Marwanto, Y. D., Liwanda, N., & Nurcholis, W. (2023). Effects of Solvent Combinations of Phenolics and Antioxidants Extraction from Kaempferia rotunda Rhizomes. International Journal of Chemical and Biochemical Sciences, 23(3), 206-210.

Singh, A., Singh, N., Singh, S., Srivastava, R. P., Singh, L., Verma, P. C., Devkota, H. P., Rahman, L. U., Rajak, B. K., Singh, A., & Saxena, G. (2023). The Industrially Important Genus Kaempferia: An Ethnopharmacological Review. Frontiers in Pharmacology, 14(1), 1-18. https://doi.org/10.3389/fphar.2023.1099523

Sultana, Z., Mohammad, F., Azam, S., Rahman, S., Rahman, S., Islam, F., & Rahmatullah, M. (2012). Evaluation of Antihyperglycemic and Antinociceptive Activities of Methanolic Extract of Kaempferia rotunda L. (Zingiberaceae) Rhizomes. Advances in Natural and Applied Sciences, 6(8), 1302-1306.

Suphrom, N., Sonyot, W., Insumrong, K., Sawangsup, P., Sutamuang, P., & Ingkaninan, K. (2017). GC-MS Analysis and In Vitro Anti-Androgenic Activity of Kaempferia rotunda Linn Extract. Asian Health, Science and Technology Reports, 25(4), 34-43.

Utami, N. W. (2019). Pertumbuhan Kaempferia rotunda L. dengan Perlakuan Variasi Jumlah Umbi Semu dan Penambahan Pupuk Organik. Biota : Jurnal Ilmiah Ilmu-ilmu Hayati, 10(1), 36-42. https://doi.org/10.24002/biota.v10i1.2797

Yadav, S., Sharma, A., & Sharma, M. C. (2023). Investigation of the Wound Healing Potential of Kaempferia rotunda (Ginger) Extract. Advances in Bioresearch, 14(4), 149-153. https://doi.org/10.15515/abr.0976-4585.14.4.149153