Toksisitas Akut Dermal Senyawa Mengkudu (Morinda citrifolia L.): Literature Review

Authors

  • Herman Widjaja Program Studi Sarjana Farmasi, Fakultas Farmasi, Universitas 17 Agustus 1945 Jakarta, Jalan Sunter Permai Raya, Jakarta Utara, Daerah Khusus Ibukota Jakarta 14350, Indonesia
  • Aryanilo Aryanilo Program Studi Sarjana Farmasi, Fakultas Farmasi, Universitas 17 Agustus 1945 Jakarta, Jalan Sunter Permai Raya, Jakarta Utara, Daerah Khusus Ibukota Jakarta 14350, Indonesia
  • Adylla Adawyah Haryana Program Studi Sarjana Farmasi, Fakultas Farmasi, Universitas 17 Agustus 1945 Jakarta, Jalan Sunter Permai Raya, Jakarta Utara, Daerah Khusus Ibukota Jakarta 14350, Indonesia
  • Junaida Pramesti Program Studi Sarjana Farmasi, Fakultas Farmasi, Universitas 17 Agustus 1945 Jakarta, Jalan Sunter Permai Raya, Jakarta Utara, Daerah Khusus Ibukota Jakarta 14350, Indonesia
  • Mario Parningotan Hutapea Program Studi Sarjana Farmasi, Fakultas Farmasi, Universitas 17 Agustus 1945 Jakarta, Jalan Sunter Permai Raya, Jakarta Utara, Daerah Khusus Ibukota Jakarta 14350, Indonesia
  • Susana Jelita Lestari Tandang Program Studi Sarjana Farmasi, Fakultas Farmasi, Universitas 17 Agustus 1945 Jakarta, Jalan Sunter Permai Raya, Jakarta Utara, Daerah Khusus Ibukota Jakarta 14350, Indonesia
  • Pida Khaerunisa Program Studi Sarjana Farmasi, Fakultas Farmasi, Universitas 17 Agustus 1945 Jakarta, Jalan Sunter Permai Raya, Jakarta Utara, Daerah Khusus Ibukota Jakarta 14350, Indonesia
  • Raditha Dellafanny Program Studi Sarjana Farmasi, Fakultas Farmasi, Universitas 17 Agustus 1945 Jakarta, Jalan Sunter Permai Raya, Jakarta Utara, Daerah Khusus Ibukota Jakarta 14350, Indonesia
  • Fulgencia Maria Amelia De Jesus Soares Program Studi Sarjana Farmasi, Fakultas Farmasi, Universitas 17 Agustus 1945 Jakarta, Jalan Sunter Permai Raya, Jakarta Utara, Daerah Khusus Ibukota Jakarta 14350, Indonesia
  • Winda Novaliani Program Studi Sarjana Farmasi, Fakultas Farmasi, Universitas 17 Agustus 1945 Jakarta, Jalan Sunter Permai Raya, Jakarta Utara, Daerah Khusus Ibukota Jakarta 14350, Indonesia

DOI:

https://doi.org/10.36312/educatoria.v6i3.1241

Keywords:

Topical Safety, Morinda citrifolia, Medicinal Plant, Acute Dermal Toxicity

Abstract

Noni (Morinda citrifolia L.) is a medicinal plant widely used in traditional medicine due to its various pharmacological activities, such as anti-inflammatory, antibacterial, and antioxidant properties. However, the topical use of natural products requires safety evaluation to ensure they do not cause toxic effects on the skin. This article aims to review studies regarding the acute dermal toxicity of noni compounds and to assess their safety based on the toxicological parameters employed. A systematic literature review was conducted by searching scientific databases such as PubMed, Scopus, and Google Scholar. The findings indicate that noni extracts generally exhibit low dermal toxicity and do not cause mortality or significant clinical changes in test animals at specific dosages. However, some studies have reported instances of mild, transient irritation. Thus, noni shows potential for safe development as a topical preparation, although further research is required to confirm the safety of long-term use.

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References

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Published

2026-07-27

How to Cite

Widjaja, H., Aryanilo, A., Haryana, A. A., Pramesti, J., Hutapea, M. P., Tandang, S. J. L., Khaerunisa, P., Dellafanny, R., Soares, F. M. A. D. J., & Novaliani, W. (2026). Toksisitas Akut Dermal Senyawa Mengkudu (Morinda citrifolia L.): Literature Review. Educatoria : Jurnal Ilmiah Ilmu Pendidikan, 6(3), 848–854. https://doi.org/10.36312/educatoria.v6i3.1241

Issue

Vol. 6 No. 3 (2026): July (In Progress)

Section

Articles

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Copyright (c) 2026 Herman Widjaja, Aryanilo, Adylla Adawyah Haryana, Junaida Pramesti, Mario Parningotan Hutapea, Susana Jelita Lestari Tandang, Pida Khaerunisa, Raditha Dellafanny, Fulgencia Maria Amelia De Jesus Soares, & Winda Novaliani

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